Androgen Receptor beta 2 antibody (pSer346)

Catalog No. ABIN7219876

The Rabbit Polyclonal anti-Androgen Receptor beta 2 antibody is suitable to detect Androgen Receptor beta 2 in samples from Human, Mouse and Rat. It has been validated for ELISA, WB, IHC and IF.

Quick Overview for Androgen Receptor beta 2 antibody (pSer346) (ABIN7219876)

Target: Androgen Receptor beta 2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Androgen Receptor beta 2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Androgen Receptor beta 2 Antibody

Binding Specificity: pSer346

Purpose: Rabbit Anti-AR-β2 (phospho Ser346) Polyclonal Antibody

Specificity: Phospho-AR-β2 (S346) Polyclonal Antibody detects endogenous levels of AR-β2 protein only when phosphorylated at S346.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human AR-beta2 Phospho-Ser346

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Androgen Receptor beta 2

Target: Androgen Receptor beta 2

Alternative Name: AR-beta2

Background: ADRB2, ADRB2R, B2AR, Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptorADRB2 encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. ADRB2 is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.

Molecular Weight: 40kD

Gene ID: 154

UniProt: P07550