AMH antibody (AA 380-460)

Catalog No. ABIN7229680

This anti-AMH antibody is a Rabbit Polyclonal antibody detecting AMH in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for AMH antibody (AA 380-460) (ABIN7229680)

Target: AMH (Anti-Mullerian Hormone (AMH))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AMH antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-AMH Antibody

Binding Specificity: AA 380-460

Purpose: MIS Polyclonal Antibody

Specificity: The antibody detects endogenous levels of MIS protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human MIS protein at AA range: 380-460

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for AMH

Target: AMH (Anti-Mullerian Hormone (AMH))

Alternative Name: MIS

Background: Rabbit Anti-MIS Polyclonal Antibody,Anti-Muellerian hormone, AMH, Muellerian-inhibiting substance, MIS,AMH encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome.,MIS

Molecular Weight: observerd band 61kDa

Gene ID: 268

UniProt: P03971

Pathways: Negative Regulation of Hormone Secretion