APITD1 antibody (AA 70-150)

Catalog No. ABIN7227850

This Rabbit Polyclonal antibody specifically detects APITD1 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for APITD1 antibody (AA 70-150) (ABIN7227850)

Target: APITD1 (Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APITD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-APITD1 Antibody

Binding Specificity: AA 70-150

Purpose: Rabbit Anti-CENPS Polyclonal Antibody

Specificity: The antibody detects endogenous levels of CENPS protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human CENPS protein at AA range: 70-150

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for APITD1

Target: APITD1 (Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1))

Alternative Name: CENPS

Background: Centromere protein S, CENP-S, Apoptosis-inducing TAF9-like domain-containing protein 1, FANCM-associated histone fold protein 1, FANCM-interacting histone fold protein 1, Fanconi anemia-associated polypeptide of 16 kDaCENPS (Centromere Protein S) was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF (II) 31, which is required for p53-mediated transcription activation. CENPS was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants.

Molecular Weight: 15kD

Gene ID: 100526739

UniProt: Q8N2Z9