AVEN antibody (AA 270-350)

Catalog No. ABIN7213740

The Rabbit Polyclonal anti-AVEN antibody is suitable to detect AVEN in samples from Human and Monkey. It has been validated for WB, ELISA, IHC and IF.

Quick Overview for AVEN antibody (AA 270-350) (ABIN7213740)

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AVEN antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-AVEN Antibody

Binding Specificity: AA 270-350

Purpose: Rabbit Anti-Aven Polyclonal Antibody

Specificity: Aven Polyclonal Antibody detects endogenous levels of Aven protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human Aven at AA range: 270-350

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for AVEN

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Alternative Name: Aven

Background: AVEN, Cell death regulator AvenAVEN, a cell death regulator, is an important signal inducer in acute leuke-mias. AVEN is a highly conserved peripheral membrane protein that protects the cell against the proteolytic activation of caspases as well as Apaf-1 mediated apoptosis by interfering with Apaf-1's ability to self-associate. Bcl-2 and Bad also interact with AVEN to prevent apoptosis. AVEN is highly expressed in ovary, heart, thymus, spleen, testis and colon, but can also be detected in other tissues. Erythropoietin and methylprednisolone may play important roles in the expression of AVEN in cardiac tissue, especially after a traumatic brain injury. In young patients suffering from acute lymphoblastic leukemia (ALL), AVEN expression may be a useful tool in prognosis prediction.

Molecular Weight: 55kD

Gene ID: 57099

UniProt: Q9NQS1