BDKRB1 antibody (AA 180-260)

Catalog No. ABIN7224134

The Rabbit Polyclonal anti-BDKRB1 antibody is suitable to detect BDKRB1 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IF.

Quick Overview for BDKRB1 antibody (AA 180-260) (ABIN7224134)

Target: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BDKRB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-BDKRB1 Antibody

Binding Specificity: AA 180-260

Purpose: Rabbit Anti-Bradykinin B1 R Polyclonal Antibody

Specificity: Bradykinin B1 R Polyclonal Antibody detects endogenous levels of Bradykinin B1 R protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Bradykinin B1 R at AA range: 180-260

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IF 1:200-1:1000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for BDKRB1

Target: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Alternative Name: Bradykinin B1 R

Background: BDKRB1, BRADYB1, B1 bradykinin receptor, B1R, BK-1 receptorBradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by BDKRB1 (bradykinin receptor B1) is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for BDKRB1.

Molecular Weight: 40kD

Gene ID: 623

UniProt: P46663

Pathways: ACE Inhibitor Pathway