BTBD6 antibody (AA 60-140)

Catalog No. ABIN7225764

The Rabbit Polyclonal anti-BTBD6 antibody is suitable to detect BTBD6 in samples from Human and Mouse. It has been validated for WB, IHC, ELISA and IF.

Quick Overview for BTBD6 antibody (AA 60-140) (ABIN7225764)

Target: BTBD6 (BTB (POZ) Domain Containing 6 (BTBD6))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BTBD6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-BTBD6 Antibody

Binding Specificity: AA 60-140

Purpose: Rabbit Anti-BTBD6 Polyclonal Antibody

Specificity: BTBD6 Polyclonal Antibody detects endogenous levels of BTBD6 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human BTBD6 at AA range: 60-140

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:10000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for BTBD6

Target: BTBD6 (BTB (POZ) Domain Containing 6 (BTBD6))

Alternative Name: BTBD6

Background: BTBD6, BDPL, BTB/POZ domain-containing protein 6, Lens BTB domain proteinBTBD6 (BTB/POZ domain-containing protein 6), also known as BDPL or lens BTB domain protein, is a 410 amino acid protein that contains one BTB/POZ domain and is specifically expressed in the lens. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD6 may play a role in transcription regulation in the lens.

Molecular Weight: 45kD

Gene ID: 90135

UniProt: Q96KE9