BTN3A1/2/3 antibody (AA 41-90)

Catalog No. ABIN7227532

The Rabbit Polyclonal anti-BTN3A1/2/3 antibody (ABIN7227532) specifically detects BTN3A1/2/3 in ELISA, IF and IHC. The antibody is reactive with Human samples.

Quick Overview for BTN3A1/2/3 antibody (AA 41-90) (ABIN7227532)

Target: BTN3A1/2/3

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BTN3A1/2/3 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-BTN3A1/2/3 Antibody

Binding Specificity: AA 41-90

Purpose: Rabbit Anti-BTN3A1/2/3 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of BTN3A1/2/3

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human BTN3A1/2/3 protein at AA range: 41-90

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200,ELISA 1:10000-20000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for BTN3A1/2/3

Target: BTN3A1/2/3

Background: Butyrophilin subfamily 3 member A1, CD277, BTN3A1, BTF5The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g. BTN2A1, MIM 613590) and BTN3 (e.g. BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al. 2010 [PubMed 20208008]). BTN3A1 (Butyrophilin Subfamily 3 Member A1) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: ligand-Receptor Interactions and Butyrophilin (BTN) family interactions. An important paralog of BTN3A1 is BTN3A3.

Gene ID: 11119

UniProt: O00481, P78410, O00478