CASR antibody

Catalog No. ABIN7225430

The Rabbit Polyclonal anti-CASR antibody has been validated for WB, ELISA and IHC (p). It is suitable to detect CASR in samples from Human, Mouse and Rat.

Quick Overview for CASR antibody (ABIN7225430)

Target: CASR (Calcium-Sensing Receptor (CASR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CASR Antibody

Purpose: CaSR Polyclonal Antibody

Specificity: CaSR Polyclonal Antibody detects endogenous levels of CaSR protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human CaSR around the non-phosphorylation site of T888

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for CASR

Target: CASR (Calcium-Sensing Receptor (CASR))

Alternative Name: CaSR

Background: Rabbit Anti-CaSR Polyclonal Antibody,CASR, GPRC2A, PCAR1, Extracellular calcium-sensing receptor, CaSR, Parathyroid cell calcium-sensing receptor, PCaR1,The protein encoded by CASR (calcium sensing receptor) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in CASR cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.,Extracellular calcium-sensing receptor

Molecular Weight: observerd band 140kDa

Gene ID: 846

UniProt: P41180

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis