CIC antibody (AA 550-630)

Catalog No. ABIN7227904

The Rabbit Polyclonal anti-CIC antibody (ABIN7227904) specifically detects CIC in WB and ELISA. The antibody is reactive with Mouse and Human samples.

Quick Overview for CIC antibody (AA 550-630) (ABIN7227904)

Target: CIC (Capicua Homolog (CIC))

Reactivity: Mouse, Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIC antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CIC Antibody

Binding Specificity: AA 550-630

Purpose: Rabbit Anti-CIC Polyclonal Antibody

Specificity: The antibody detects endogenous levels of CIC protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human CIC protein at AA range: 550-630

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CIC

Target: CIC (Capicua Homolog (CIC))

Alternative Name: CIC

Background: Protein capicua homologCIC encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID: 6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID: 21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID: 100288687) and FOXO4 (GeneID: 4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 176kD

Gene ID: 23152

UniProt: Q96RK0