CA8 antibody (Internal Region)

Catalog No. ABIN7225002

This anti-CA8 antibody is a Rabbit Polyclonal antibody detecting CA8 in ELISA and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for CA8 antibody (Internal Region) (ABIN7225002)

Target: CA8 (Carbonic Anhydrase VIII (CA8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CA8 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CA8 Antibody

Binding Specificity: Internal Region

Purpose: CA VIII Polyclonal Antibody

Specificity: CA VIII Polyclonal Antibody detects endogenous levels of CA VIII protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human CA VIII

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for CA8

Target: CA8 (Carbonic Anhydrase VIII (CA8))

Alternative Name: CA VIII

Background: Rabbit Anti-CA VIII Polyclonal Antibody,CA8, CALS, Carbonic anhydrase-related protein, CARP, Carbonic anhydrase VIII, CA-VIII,The protein encoded by CA8 (carbonic anhydrase 8) was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e. The reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in CA8 are associated with osteoporosis, and overexpression of CA8 in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants.,Carbonic anhydrase-related protein

Gene ID: 767

UniProt: P35219