Caspase 7 p20 antibody (Cleaved-Asp198)

Catalog No. ABIN7212446

The Rabbit Polyclonal anti-Caspase 7 p20 antibody (ABIN7212446) specifically detects Caspase 7 p20 in ELISA and WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for Caspase 7 p20 antibody (Cleaved-Asp198) (ABIN7212446)

Target: Caspase 7 p20

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 7 p20 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-Caspase 7 p20 Antibody

Binding Specificity: AA 120-200, Cleaved-Asp198

Purpose: Rabbit Anti-Cleaved-Caspase-7 p20 (D198) Polyclonal Antibody

Specificity: Cleaved-Caspase-7 p20 (D198) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-7 p20 protein resulting from cleavage adjacent to D198.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Caspase-7 p20 at AA range: 120-200

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Caspase 7 p20

Target: Caspase 7 p20

Alternative Name: Caspase-7 p20

Background: CASP7, MCH3, Caspase-7, CASP-7, Apoptotic protease Mch-3, CMH-1, ICE-like apoptotic protease 3, ICE-LAP3CASP7 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of caspase 7 is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Molecular Weight: 20kD

Gene ID: 840

UniProt: P55210