Cathepsin G antibody (Cleaved-Ile21)

Catalog No. ABIN7212462

The Rabbit Polyclonal anti-Cathepsin G antibody is suitable to detect Cathepsin G in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for Cathepsin G antibody (Cleaved-Ile21) (ABIN7212462)

Target: Cathepsin G (CTSG)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin G antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Cathepsin G Antibody

Binding Specificity: AA 10-90, Cleaved-Ile21

Purpose: Rabbit Anti-Cleaved-Cathepsin G (I21) Polyclonal Antibody

Specificity: Cleaved-Cathepsin G (I21) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin G protein resulting from cleavage adjacent to I21.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human Cathepsin G at AA range: 10-90

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Cathepsin G

Target: Cathepsin G (CTSG)

Alternative Name: Cathepsin G

Background: CTSG, Cathepsin G, CGThe protein encoded by CTSG, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease (cathepsin G) has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, cathepsin G is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this CTSG.

Molecular Weight: 28kD,26kD

Gene ID: 1511

UniProt: P08311

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones