CD70 antibody (AA 150-193)

Catalog No. ABIN7227764

The Rabbit Polyclonal anti-CD70 antibody is suitable to detect CD70 in samples from Human and Mouse. It has been validated for ELISA, IHC and IF.

Quick Overview for CD70 antibody (AA 150-193) (ABIN7227764)

Target: CD70 (CD70 Molecule (CD70))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD70 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-CD70 Antibody

Binding Specificity: AA 150-193

Purpose: Rabbit Anti-CD70 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of CD70

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human CD70 protein at AA range: 150-193

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200,ELISA 1:10000-20000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CD70

Target: CD70 (CD70 Molecule (CD70))

Alternative Name: CD70

Background: CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD antigen CD70The protein encoded by CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include Acute Myocarditis and Lymphoproliferative Syndrome 2. Among its related pathways are T Cell Co-Signaling Pathway: ligand-Receptor Interactions and Akt Signaling. is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include Acute Myocarditis and Lymphoproliferative Syndrome 2. Among its related pathways are T Cell Co-Signaling Pathway: ligand-Receptor Interactions and Akt Signaling.

Gene ID: 970

UniProt: P32970

Pathways: Cancer Immune Checkpoints