CLK2 antibody (AA 1-80)

Catalog No. ABIN7214246

The Rabbit Polyclonal anti-CLK2 antibody is suitable to detect CLK2 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IHC and IF.

Quick Overview for CLK2 antibody (AA 1-80) (ABIN7214246)

Target: CLK2 (CDC-Like Kinase 2 (CLK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-CLK2 Antibody

Binding Specificity: AA 1-80

Purpose: Rabbit Anti-CLK2 Polyclonal Antibody

Specificity: CLK2 Polyclonal Antibody detects endogenous levels of CLK2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human CLK2 at AA range: 1-80

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:20000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CLK2

Target: CLK2 (CDC-Like Kinase 2 (CLK2))

Alternative Name: CLK2

Background: CLK2, Dual specificity protein kinase CLK2, CDC-like kinase 2CLK2 encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29 kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that CLK2 is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for CLK2 on chromosome 7. Alternative splicing results in multiple transcript variants.

Molecular Weight: 60kD

Gene ID: 1196

UniProt: P49760

Pathways: Regulation of Carbohydrate Metabolic Process