CABLES1 antibody (AA 530-610)

Catalog No. ABIN7213900

The Rabbit Polyclonal anti-CABLES1 antibody is suitable to detect CABLES1 in samples from Human and Mouse. It has been validated for WB, ELISA, IHC and IF.

Quick Overview for CABLES1 antibody (AA 530-610) (ABIN7213900)

Target: CABLES1 (Cdk5 and Abl Enzyme Substrate 1 (CABLES1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CABLES1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-CABLES1 Antibody

Binding Specificity: AA 530-610

Purpose: Rabbit Anti-Cables1 Polyclonal Antibody

Specificity: Cables1 Polyclonal Antibody detects endogenous levels of Cables1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human Cables1 at AA range: 530-610

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CABLES1

Target: CABLES1 (Cdk5 and Abl Enzyme Substrate 1 (CABLES1))

Alternative Name: Cables1

Background: CABLES1, CABLES, CDK5 and ABL1 enzyme substrate 1, Interactor with CDK3 1, Ik3-1CABLES1 encodes a protein (Cdk5 and Abl enzyme substrate 1) involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127). Multiple transcript variants encoding different isoforms have been found for CABLES1.

Molecular Weight: 67kD

Gene ID: 91768

UniProt: Q8TDN4