CIDEB antibody (AA 60-140)

Catalog No. ABIN7214210

The Rabbit Polyclonal anti-CIDEB antibody (ABIN7214210) specifically detects CIDEB in ELISA, WB, IHC and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for CIDEB antibody (AA 60-140) (ABIN7214210)

Target: CIDEB (Cell Death-Inducing DFFA-Like Effector B (CIDEB))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIDEB antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-CIDEB Antibody

Binding Specificity: AA 60-140

Purpose: Rabbit Anti-CIDE-B Polyclonal Antibody

Specificity: CIDE-B Polyclonal Antibody detects endogenous levels of CIDE-B protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human CIDE-B at AA range: 60-140

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CIDEB

Target: CIDEB (Cell Death-Inducing DFFA-Like Effector B (CIDEB))

Alternative Name: CIDE-B

Background: CIDEB, Cell death activator CIDE-B, Cell death-inducing DFFA-like effector BApoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-B induces apoptosis, which is inhibited by DFF45. CIDE-B is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-B is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes and bone marrow.

Molecular Weight: 24kD

Gene ID: 27141

UniProt: Q9UHD4