CENPJ antibody (AA 510-590)

Catalog No. ABIN7227832

This Rabbit Polyclonal antibody specifically detects CENPJ in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for CENPJ antibody (AA 510-590) (ABIN7227832)

Target: CENPJ (Centromere Protein J (CENPJ))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CENPJ antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CENPJ Antibody

Binding Specificity: AA 510-590

Purpose: Rabbit Anti-CENPJ Polyclonal Antibody

Specificity: The antibody detects endogenous levels of CENPJ protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human CENPJ protein at AA range: 510-590

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CENPJ

Target: CENPJ (Centromere Protein J (CENPJ))

Alternative Name: CENPJ

Background: Centromere protein J, CENP-J, Centrosomal P4.1-associated protein, LAG-3-associated protein, LYST-interacting protein 1CENPJ (Centromere Protein J) encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in CENPJ are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for CENPJ.

Molecular Weight: 147kD

Gene ID: 55835

UniProt: Q9HC77

Pathways: M Phase