CCR8 antibody (AA 250-330)

Catalog No. ABIN7227676

The Rabbit Polyclonal anti-CCR8 antibody is suitable to detect CCR8 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for CCR8 antibody (AA 250-330) (ABIN7227676)

Target: CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CCR8 Antibody

Binding Specificity: AA 250-330

Purpose: Rabbit Anti-CCR8 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of CCR8 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human CCR8 protein at AA range: 250-330

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CCR8

Target: CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))

Alternative Name: CCR8

Background: C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CC chemokine receptor CHEMR1, CMKBRL2, Chemokine receptor-like 1, CKR-L1, GPR-CY6, GPRCY6, TER1, CD_antigen: CDw198CCR8 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. CCR8 is located at the chemokine receptor gene cluster region.

Molecular Weight: 39kD

Gene ID: 1237

UniProt: P51685