CLCNKA antibody (AA 550-630)

Catalog No. ABIN7214232

This Rabbit Polyclonal antibody specifically detects CLCNKA in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CLCNKA antibody (AA 550-630) (ABIN7214232)

Target: CLCNKA (Chloride Channel Ka (CLCNKA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLCNKA antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CLCNKA Antibody

Binding Specificity: AA 550-630

Purpose: Rabbit Anti-CLC-KA Polyclonal Antibody

Specificity: CLC-KA Polyclonal Antibody detects endogenous levels of CLC-KA protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human CLC-KA at AA range: 550-630

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CLCNKA

Target: CLCNKA (Chloride Channel Ka (CLCNKA))

Alternative Name: CLC-KA

Background: CLCNKA, Chloride channel protein ClC-Ka, Chloride channel Ka, ClC-K1CLCNKA is a member of the CLC family of voltage-gated chloride channels. The encoded protein (chloride voltage-gated channel Ka) is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for CLCNKA.

Molecular Weight: 75kD

Gene ID: 1187

UniProt: P51800

Pathways: Response to Water Deprivation