CSH1 antibody (AA 161-210)

Catalog No. ABIN7226954

This Rabbit Polyclonal antibody specifically detects CSH1 in WB, IHC, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for CSH1 antibody (AA 161-210) (ABIN7226954)

Target: CSH1 (Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) (CSH1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSH1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-CSH1 Antibody

Binding Specificity: AA 161-210

Purpose: Rabbit Anti-CSH1 Polyclonal Antibody

Specificity: The antibody detects endogenous CSH1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthetic peptide from human protein at AA range: 161-210

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC: 100-300,WB 1:500-2000,ELISA 1:10000-20000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CSH1

Target: CSH1 (Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) (CSH1))

Alternative Name: CSH1

Background: CSH1, CSH2The protein encoded by CSH1 (chorionic somatomammotropin hormone 1) is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. CSH1 is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation, an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in CSH1 result in placental lactogen deficiency and Silver-Russell syndrome.

Molecular Weight: 25kD

Gene ID: 1442

UniProt: P01243

Pathways: Response to Growth Hormone Stimulus