Claudin 19 antibody (AA 50-130)

Catalog No. ABIN7214214

This Rabbit Polyclonal antibody specifically detects Claudin 19 in WB and ELISA. It exhibits reactivity toward Human and Rat.

Quick Overview for Claudin 19 antibody (AA 50-130) (ABIN7214214)

Target: Claudin 19 (CLDN19)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 19 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Claudin 19 Antibody

Binding Specificity: AA 50-130

Purpose: Rabbit Anti-Claudin-19 Polyclonal Antibody

Specificity: Claudin-19 Polyclonal Antibody detects endogenous levels of Claudin-19 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Claudin-19 at AA range: 50-130

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Claudin 19

Target: Claudin 19 (CLDN19)

Alternative Name: Claudin-19

Background: CLDN19, Claudin-19The product of CLDN19 belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in CLDN19 are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for CLDN19.

Molecular Weight: 23kD

Gene ID: 149461

UniProt: Q8N6F1

Pathways: Cell-Cell Junction Organization, Hepatitis C