CLDN8 antibody (AA 50-130)

Catalog No. ABIN7225800

The Rabbit Polyclonal anti-CLDN8 antibody (ABIN7225800) specifically detects CLDN8 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for CLDN8 antibody (AA 50-130) (ABIN7225800)

Target: CLDN8 (Claudin 8 (CLDN8))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLDN8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CLDN8 Antibody

Binding Specificity: AA 50-130

Purpose: Rabbit Anti-Claudin-8 Polyclonal Antibody

Specificity: Claudin-8 Polyclonal Antibody detects endogenous levels of Claudin-8 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Claudin-8 at AA range: 50-130

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CLDN8

Target: CLDN8 (Claudin 8 (CLDN8))

Alternative Name: Claudin-8

Background: CLDN8, Claudin-8CLDN8 (claudin 8) encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of CLDN8 has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.

Molecular Weight: 28kD

Gene ID: 9073

UniProt: P56748

Pathways: Hepatitis C