C5AR1 antibody (N-Term)

Catalog No. ABIN7226674

The Rabbit Polyclonal anti-C5AR1 antibody is suitable to detect C5AR1 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for C5AR1 antibody (N-Term) (ABIN7226674)

Target: C5AR1 (Complement Component 5a Receptor 1 (C5AR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C5AR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-C5AR1 Antibody

Binding Specificity: N-Term

Purpose: Rabbit Anti-CD88 Polyclonal Antibody

Specificity: CD88 Polyclonal Antibody detects endogenous levels of CD88 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human CD88

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for C5AR1

Target: C5AR1 (Complement Component 5a Receptor 1 (C5AR1))

Alternative Name: CD88

Background: C5AR1, C5AR, C5R1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR, CD88OPRPN (opiorphin prepropeptide) encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants.

Molecular Weight: 39kD

Gene ID: 58503

UniProt: P21730

Pathways: Complement System