C8B antibody (AA 371-420)

Catalog No. ABIN7226914

This Rabbit Polyclonal antibody specifically detects C8B in WB and ELISA. It exhibits reactivity toward Human and Rat.

Quick Overview for C8B antibody (AA 371-420) (ABIN7226914)

Target: C8B (Complement Component 8, beta Polypeptide (C8B))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C8B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-C8B Antibody

Binding Specificity: AA 371-420

Purpose: Rabbit Anti-C8 β Polyclonal Antibody

Specificity: C8 β Polyclonal Antibody detects endogenous levels of C8 β.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C8 beta at AA range: 371-420

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for C8B

Target: C8B (Complement Component 8, beta Polypeptide (C8B))

Alternative Name: C8 beta

Background: Complement component C8 beta chain, Complement component 8 subunit betaC8B (complement C8 beta chain) encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants.

Molecular Weight: 70kD

Gene ID: 732

UniProt: P07358

Pathways: Complement System