COX11 antibody (AA 30-110)

Catalog No. ABIN7219602

The Rabbit Polyclonal anti-COX11 antibody (ABIN7219602) specifically detects COX11 in ELISA, WB, IHC and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for COX11 antibody (AA 30-110) (ABIN7219602)

Target: COX11 (COX11 Cytochrome C Oxidase Assembly (COX11))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COX11 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-COX11 Antibody

Binding Specificity: AA 30-110

Purpose: Rabbit Anti-COX11 Polyclonal Antibody

Specificity: COX11 Polyclonal Antibody detects endogenous levels of COX11 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human COX11 at AA range: 30-110

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for COX11

Target: COX11 (COX11 Cytochrome C Oxidase Assembly (COX11))

Alternative Name: COX11

Background: COX11, Cytochrome c oxidase assembly protein COX11, mitochondrialCytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. COX11 encodes COX11, cytochrome c oxidase copper chaperone which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6.

Molecular Weight: 31kD

Gene ID: 1353

UniProt: Q9Y6N1

Pathways: Regulation of Carbohydrate Metabolic Process