CNGA1 antibody (AA 370-450)

Catalog No. ABIN7219474

This anti-CNGA1 antibody is a Rabbit Polyclonal antibody detecting CNGA1 in ELISA and WB. Suitable for Human, Rat and Mouse.

Quick Overview for CNGA1 antibody (AA 370-450) (ABIN7219474)

Target: CNGA1 (Cyclic Nucleotide Gated Channel alpha 1 (CNGA1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNGA1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-CNGA1 Antibody

Binding Specificity: AA 370-450

Purpose: CNG-1 Polyclonal Antibody

Specificity: CNG-1 Polyclonal Antibody detects endogenous levels of CNG-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human CNG-1 at AA range: 370-450

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for CNGA1

Target: CNGA1 (Cyclic Nucleotide Gated Channel alpha 1 (CNGA1))

Alternative Name: CNG-1

Background: Rabbit Anti-CNG-1 Polyclonal Antibody,CNGA1, CNCG, CNCG1, cGMP-gated cation channel alpha-1, Cyclic nucleotide-gated cation channel 1, Cyclic nucleotide-gated channel alpha-1, CNG channel alpha-1, CNG-1, CNG1, Cyclic nucleotide-gated channel, photoreceptor, Rod photoreceptor cG,The cyclic nucleotide gated channel alpha 1 encoded by CNGA1 is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene.,cGMP-gated cation channel alpha-1

Molecular Weight: observerd band 80kDa

Gene ID: 1259

UniProt: P29973

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction, Asymmetric Protein Localization