GARP antibody (AA 540-620)

Catalog No. ABIN7214266

The Rabbit Polyclonal anti-GARP antibody (ABIN7214266) specifically detects GARP in ELISA and WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for GARP antibody (AA 540-620) (ABIN7214266)

Target: GARP (CNGB1) (Cyclic Nucleotide Gated Channel beta 1 (CNGB1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GARP antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-GARP Antibody

Binding Specificity: AA 540-620

Purpose: Rabbit Anti-CNG-1β Polyclonal Antibody

Specificity: CNG-1β Polyclonal Antibody detects endogenous levels of CNG-1β protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human CNG-1beta at AA range: 540-620

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GARP

Target: GARP (CNGB1) (Cyclic Nucleotide Gated Channel beta 1 (CNGB1))

Alternative Name: CNG-1beta

Background: CNGB1, CNCG2, CNCG3L, CNCG4, RCNC2, Cyclic nucleotide-gated cation channel beta-1, Cyclic nucleotide-gated cation channel 4, CNG channel 4, CNG-4, CNG4, Cyclic nucleotide-gated cation channel gamma, Cyclic nucleotide-gated cation channel moIn humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in CNGB1 are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for CNGB1.

Molecular Weight: 102kD

Gene ID: 1258

UniProt: Q14028

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction