Cytohesin 3 antibody (C-Term)

Catalog No. ABIN7215170

The Rabbit Polyclonal anti-Cytohesin 3 antibody is suitable to detect Cytohesin 3 in samples from Human, Mouse, Rat and Monkey. It has been validated for WB and ELISA.

Quick Overview for Cytohesin 3 antibody (C-Term) (ABIN7215170)

Target: Cytohesin 3 (CYTH3)

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cytohesin 3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Cytohesin 3 Antibody

Binding Specificity: C-Term

Purpose: Rabbit Anti-GRP1 Polyclonal Antibody

Specificity: GRP1 Polyclonal Antibody detects endogenous levels of GRP1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human GRP1

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Cytohesin 3

Target: Cytohesin 3 (CYTH3)

Alternative Name: GRP1

Background: CYTH3, ARNO3, GRP1, PSCD3, Cytohesin-3, ARF nucleotide-binding site opener 3, Protein ARNO3, General receptor of phosphoinositides 1, Grp1, PH, SEC7 and coiled-coil domain-containing protein 3CYTH3 encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. Cytohesin-3 is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.

Molecular Weight: 46kD

Gene ID: 9265

UniProt: O43739