DOCK1 antibody (AA 1630-1710)

Catalog No. ABIN7220068

The Rabbit Polyclonal anti-DOCK1 antibody (ABIN7220068) specifically detects DOCK1 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for DOCK1 antibody (AA 1630-1710) (ABIN7220068)

Target: DOCK1 (Dedicator of Cytokinesis 1 (DOCK1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOCK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-DOCK1 Antibody

Binding Specificity: AA 1630-1710

Purpose: Rabbit Anti-DOCK 180 Polyclonal Antibody

Specificity: DOCK 180 Polyclonal Antibody detects endogenous levels of DOCK 180 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human DOCK 180 at AA range: 1630-1710

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for DOCK1

Target: DOCK1 (Dedicator of Cytokinesis 1 (DOCK1))

Alternative Name: DOCK 180

Background: DOCK1, Dedicator of cytokinesis protein 1, 180 kDa protein downstream of CRK, DOCK180DOCK1 encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. Dedicator of cytokinesis protein 1 regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants.

Molecular Weight: 215kD

Gene ID: 1793

UniProt: Q14185

Pathways: Signaling of Hepatocyte Growth Factor Receptor