DHRS2 antibody (AA 80-160)

Catalog No. ABIN7214562

This anti-DHRS2 antibody is a Rabbit Polyclonal antibody detecting DHRS2 in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for DHRS2 antibody (AA 80-160) (ABIN7214562)

Target: DHRS2 (Dehydrogenase/reductase (SDR Family) Member 2 (DHRS2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DHRS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-DHRS2 Antibody

Binding Specificity: AA 80-160

Purpose: DHRS2 Polyclonal Antibody

Specificity: DHRS2 Polyclonal Antibody detects endogenous levels of DHRS2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human DHRS2 at AA range: 80-160

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for DHRS2

Target: DHRS2 (Dehydrogenase/reductase (SDR Family) Member 2 (DHRS2))

Alternative Name: DHRS2

Background: Rabbit Anti-DHRS2 Polyclonal Antibody,DHRS2, Dehydrogenase/reductase SDR family member 2, Dicarbonyl reductase HEP27, Protein D,DHRS2 (dehydrogenase/reductase (SDR family) member 2), also known as SDR25C1 or HEP27, is a 258 amino acid protein that localizes to the nucleus and belongs to the short-chain dehydrogenase/reductase (SDR) family. Functioning as an NADPH-dependent dicarbonyl reductase, DHRS2 is thought to inhibit cell replication by either converting cortisone in cortisol, or by catalyzing the oxidation of androgen and estrogen. The gene encoding DHRS2 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5 % of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder α1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.,Dehydrogenase

Molecular Weight: observerd band 27kDa

Gene ID: 10202

UniProt: Q13268

Pathways: C21-Steroid Hormone Metabolic Process