DLC1 antibody (AA 30-110)

Catalog No. ABIN7218974

This Rabbit Polyclonal antibody specifically detects DLC1 in IHC, ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for DLC1 antibody (AA 30-110) (ABIN7218974)

Target: DLC1 (Deleted in Liver Cancer 1 (DLC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLC1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-DLC1 Antibody

Binding Specificity: AA 30-110

Purpose: Rabbit Anti-DLC-1 Polyclonal Antibody

Specificity: DLC-1 Polyclonal Antibody detects endogenous levels of DLC-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human DLC-1 at AA range: 30-110

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for DLC1

Target: DLC1 (Deleted in Liver Cancer 1 (DLC1))

Alternative Name: DLC-1

Background: DLC1, ARHGAP7, KIAA1723, STARD12, Rho GTPase-activating protein 7, Deleted in liver cancer 1 protein, DLC-1, HP protein, Rho-type GTPase-activating protein 7, START domain-containing protein 12, StARD12, StAR-related lipid transfer proteinDLC1 encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.

Gene ID: 10395

UniProt: Q96QB1

Pathways: Tube Formation, Positive Regulation of Endopeptidase Activity