DENND5A antibody (AA 650-730)

Catalog No. ABIN7228184

This Rabbit Polyclonal antibody specifically detects DENND5A in ELISA and WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for DENND5A antibody (AA 650-730) (ABIN7228184)

Target: DENND5A (DENN/MADD Domain Containing 5A (DENND5A))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DENND5A antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-DENND5A Antibody

Binding Specificity: AA 650-730

Purpose: Rabbit Anti-DEN5A Polyclonal Antibody

Specificity: The antibody detects endogenous levels of DEN5A protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human DEN5A protein at AA range: 650-730

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for DENND5A

Target: DENND5A (DENN/MADD Domain Containing 5A (DENND5A))

Alternative Name: DEN5A

Background: DENN domain-containing protein 5A, Rab6-interacting protein 1, Rab6IP1DENND5A (DENN Domain Containing 5A) encodes a DENN-domain-containing protein that functions as a RAB-activating guanine nucleotide exchange factor (GEF). This protein catalyzes the conversion of GDP to GTP and thereby converts inactive GDP-bound Rab proteins into their active GTP-bound form. The encoded protein is recruited by RAB6 onto Golgi membranes and is therefore referred to as RAB6-interacting protein 1. This protein binds with RAB39 as well. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Mutations in DENND5A are associated with early infantile epileptic encephalopathy-49.

Molecular Weight: 141kD

Gene ID: 23258

UniProt: Q6IQ26