Desmoglein 2 antibody (AA 370-450)

Catalog No. ABIN7220094

This Rabbit Polyclonal antibody specifically detects Desmoglein 2 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for Desmoglein 2 antibody (AA 370-450) (ABIN7220094)

Target: Desmoglein 2 (DSG2)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmoglein 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Desmoglein 2 Antibody

Binding Specificity: AA 370-450

Purpose: Rabbit Anti-Dsg2 Polyclonal Antibody

Specificity: Dsg2 Polyclonal Antibody detects endogenous levels of Dsg2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Dsg2 at AA range: 370-450

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Desmoglein 2

Target: Desmoglein 2 (DSG2)

Alternative Name: Dsg2

Background: DSG2, CDHF5, Desmoglein-2, Cadherin family member 5, HDGCDSG2 encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. DSG2 is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.

Molecular Weight: 140kD

Gene ID: 1829

UniProt: Q14126

Pathways: Cell-Cell Junction Organization