RASD2 antibody (AA 190-270)

Catalog No. ABIN7220746

The Rabbit Polyclonal anti-RASD2 antibody (ABIN7220746) specifically detects RASD2 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for RASD2 antibody (AA 190-270) (ABIN7220746)

Target: RASD2 (RASD Family, Member 2 (RASD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RASD2 Antibody

Binding Specificity: AA 190-270

Purpose: Rabbit Anti-Dexras2 Polyclonal Antibody

Specificity: Dexras2 Polyclonal Antibody detects endogenous levels of Dexras2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human Dexras2 at AA range: 190-270

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for RASD2

Target: RASD2 (RASD Family, Member 2 (RASD2))

Alternative Name: Dexras2

Background: RASD2, TEM2, GTP-binding protein Rhes, Ras homolog enriched in striatum, Tumor endothelial marker 2RASD2 belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The RASD family member 2 functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients.

Molecular Weight: 35kD

Gene ID: 23551

UniProt: Q96D21