DOK2 antibody (pTyr345)

Catalog No. ABIN7225782

This Rabbit Polyclonal antibody specifically detects DOK2 in ELISA, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for DOK2 antibody (pTyr345) (ABIN7225782)

Target: DOK2

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOK2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-DOK2 Antibody

Binding Specificity: pTyr345

Purpose: Rabbit Anti-Dok-2 (phospho Tyr345) Polyclonal Antibody

Specificity: Phospho-Dok-2 (Y345) Polyclonal Antibody detects endogenous levels of Dok-2 protein only when phosphorylated at Y345.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Dok-2 Phospho-Tyr345

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:20000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for DOK2

Target: DOK2

Alternative Name: Dok-2

Background: DOK2, Docking protein 2, Downstream of tyrosine kinase 2, p56(dok-2)The protein encoded by DOK2 (docking protein 2)is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.

Gene ID: 9046

UniProt: O60496