DYRK3 antibody (AA 1-80)

Catalog No. ABIN7228332

The Rabbit Polyclonal anti-DYRK3 antibody (ABIN7228332) specifically detects DYRK3 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for DYRK3 antibody (AA 1-80) (ABIN7228332)

Target: DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYRK3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-DYRK3 Antibody

Binding Specificity: AA 1-80

Purpose: Rabbit Anti-DYRK3 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of DYRK3 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human DYRK3 protein at AA range: 1-80

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for DYRK3

Target: DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))

Alternative Name: DYRK3

Background: Dual specificity tyrosine-phosphorylation-regulated kinase 3, Regulatory erythroid kinase, EDKDYRK3 product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight: 64kD

Gene ID: 8444

UniProt: O43781

Pathways: Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha