Endothelin 2 antibody

Catalog No. ABIN7228354

This Rabbit Polyclonal antibody specifically detects Endothelin 2 in ELISA and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Endothelin 2 antibody (ABIN7228354)

Target: Endothelin 2 (EDN2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endothelin 2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-Endothelin 2 Antibody

Purpose: Rabbit Anti-EDN2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of EDN2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human EDN2 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Endothelin 2

Target: Endothelin 2 (EDN2)

Alternative Name: EDN2

Background: Endothelin-2, ET-2, Preproendothelin-2, PPET2EDN2 encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. Endothelin 2 is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants.

Molecular Weight: 19kD

Gene ID: 1907

UniProt: P20800

Pathways: Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones