EPH Receptor A2 antibody (pTyr588)

Catalog No. ABIN7212950

The Rabbit Polyclonal anti-EPH Receptor A2 antibody has been validated for WB and ELISA. It is suitable to detect EPH Receptor A2 in samples from Human and Mouse.

Quick Overview for EPH Receptor A2 antibody (pTyr588) (ABIN7212950)

Target: EPH Receptor A2 (EPHA2)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-EPH Receptor A2 Antibody

Binding Specificity: pTyr588

Purpose: EphA2 (phospho Tyr588) Polyclonal Antibody

Specificity: Phospho-EphA2 (Y588) Polyclonal Antibody detects endogenous levels of EphA2 protein only when phosphorylated at Y588.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human EphA2 Phospho-Tyr588

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for EPH Receptor A2

Target: EPH Receptor A2 (EPHA2)

Alternative Name: EphA2

Background: Rabbit Anti-EphA2 (phospho Tyr588) Polyclonal Antibody,EPHA2, ECK, Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK,EPHA2 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EPHA2 encodes EPH receptor A2 that binds ephrin-A ligands. Mutations in EPHA2 are the cause of certain genetically-related cataract disorders.,Ephrin type-A receptor 2

Molecular Weight: observerd band 130kDa

Gene ID: 1969

UniProt: P29317

Pathways: RTK Signaling