GCN2 antibody (pThr899)

Catalog No. ABIN7222526

The Rabbit Polyclonal anti-GCN2 antibody (ABIN7222526) specifically detects GCN2 in IHC, ELISA and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for GCN2 antibody (pThr899) (ABIN7222526)

Target: GCN2 (EIF2AK4) (Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCN2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-GCN2 Antibody

Binding Specificity: pThr899

Purpose: Rabbit Anti-GCN2 (phospho Thr899) Polyclonal Antibody

Specificity: Phospho-GCN2 (T899) Polyclonal Antibody detects endogenous levels of GCN2 protein only when phosphorylated at T899.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human GCN2 Phospho-Thr899

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:5000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GCN2

Target: GCN2 (EIF2AK4) (Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4))

Alternative Name: GCN2

Background: EIF2AK4, GCN2, KIAA1338, Eukaryotic translation initiation factor 2-alpha kinase 4, GCN2-like proteinEIF2AK4 encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the down regulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.

Gene ID: 440275

UniProt: Q9P2K8

Pathways: ER-Nucleus Signaling, Hepatitis C