Exportin 7 antibody

Catalog No. ABIN7232184

The Rabbit Polyclonal anti-Exportin 7 antibody (ABIN7232184) specifically detects Exportin 7 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for Exportin 7 antibody (ABIN7232184)

Target: Exportin 7 (XPO7)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Exportin 7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Exportin 7 Antibody

Purpose: Rabbit Anti-XPO7 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of XPO7 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human XPO7 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Exportin 7

Target: Exportin 7 (XPO7)

Alternative Name: XPO7

Background: Exportin-7, Exp7, Ran-binding protein 16Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Molecular Weight: 119kD

Gene ID: 23039

UniProt: Q9UIA9