FAM3D antibody (AA 121-170)

Catalog No. ABIN7226874

The Rabbit Polyclonal anti-FAM3D antibody is suitable to detect FAM3D in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for FAM3D antibody (AA 121-170) (ABIN7226874)

Target: FAM3D (Family with Sequence Similarity 3, Member D (FAM3D))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM3D antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-FAM3D Antibody

Binding Specificity: AA 121-170

Purpose: Rabbit Anti-FAM3D Polyclonal Antibody

Specificity: FAM3D Polyclonal Antibody detects endogenous levels of FAM3D.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from FAM3D at AA range: 121-170

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for FAM3D

Target: FAM3D (Family with Sequence Similarity 3, Member D (FAM3D))

Alternative Name: FAM3D

Background: Protein FAM3DFamily with sequence similarity 3 (FAM3) family is a novel cytokine-like gene family, which has four genes in this family, FAM3A, FAM3B, FAM3C, and FAM3D, each encoding a protein (224-235 amino acids) with a hydrophobic leader sequence. It had indicated that FAM3B/PANDER (pancreatic derived factor) is highly expressed in pancreas, and FAM3A and FAM3C in almost all tissues. FAM3D is abundantly expressed in placenta and weakly expressed in small intestine. Immunohistochemistry showed that FAM3A is expressed prominently in the vascular endothelium, particularly capillaries. FAM3A and FAM3B protein were both localized to the islets of Langerhans of the endocrine pancreas. Recombinant FAM3B protein has delayed effects on beta-cell function. FAM3C is involved in retinal laminar formation processes in vertebrates. NFATC2, SCP2, CACNA1C, TCRA, POLE, and FAM3D, were associated with narcolepsy. Some of these associations were further supported by gene expression analyses and an association study in essential hypersomnia (EHS), CNS hypersonia similar to narcolepsy.

Molecular Weight: 22kD

Gene ID: 131177

UniProt: Q96BQ1