FANCM antibody

Catalog No. ABIN7228482

The Rabbit Polyclonal anti-FANCM antibody has been validated for WB and ELISA. It is suitable to detect FANCM in samples from Human.

Quick Overview for FANCM antibody (ABIN7228482)

Target: FANCM (Fanconi Anemia Complementation Group M (FANCM))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FANCM antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-FANCM Antibody

Purpose: FANCM Polyclonal Antibody

Specificity: The antibody detects endogenous levels of FANCM protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human FANCM protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for FANCM

Target: FANCM (Fanconi Anemia Complementation Group M (FANCM))

Alternative Name: FANCM

Background: Rabbit Anti-FANCM Polyclonal Antibody,Fanconi anemia group M protein, Protein FACM, ATP-dependent RNA helicase FANCM Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef ortholog,The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. FANCM (Fanconi Anemia Complementation Group M) is a Protein Coding gene. Diseases associated with FANCM include Fanconi Anemia, Complementation Group A and Fancm-Related Fanconi Anemia. Among its related pathways are Fanconi anemia pathway and DNA Double-Strand Break Repair.,FANCM

Molecular Weight: observerd band 225kDa

Gene ID: 57697

UniProt: Q8IYD8

Pathways: DNA Damage Repair