FGFRL1 antibody (AA 130-210)

Catalog No. ABIN7223224

This anti-FGFRL1 antibody is a Rabbit Polyclonal antibody detecting FGFRL1 in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for FGFRL1 antibody (AA 130-210) (ABIN7223224)

Target: FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFRL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-FGFRL1 Antibody

Binding Specificity: AA 130-210

Purpose: FGFR-5 Polyclonal Antibody

Specificity: FGFR-5 Polyclonal Antibody detects endogenous levels of FGFR-5 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human FGFR-5 at AA range: 130-210

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for FGFRL1

Target: FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))

Alternative Name: FGFR-5

Background: Rabbit Anti-FGFR-5 Polyclonal Antibody,FGFRL1, FGFR5, FHFR, Fibroblast growth factor receptor-like 1, FGF receptor-like protein 1, FGF homologous factor receptor, FGFR-like protein, Fibroblast growth factor receptor 5, FGFR-5,The protein encoded by FGFRL1 (fibroblast growth factor receptor-like 1) is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between FGFRL1 product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for FGFRL1.,Fibroblast growth factor receptor-like 1

Molecular Weight: observerd band 54kDa

Gene ID: 53834

UniProt: Q8N441

Pathways: RTK Signaling