GRK4 antibody (AA 10-90)

Catalog No. ABIN7221270

This Rabbit Polyclonal antibody specifically detects GRK4 in ELISA, IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GRK4 antibody (AA 10-90) (ABIN7221270)

Target: GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRK4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-GRK4 Antibody

Binding Specificity: AA 10-90

Purpose: Rabbit Anti-GRK 4 Polyclonal Antibody

Specificity: GRK 4 Polyclonal Antibody detects endogenous levels of GRK 4 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human GRK 4 at AA range: 10-90

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GRK4

Target: GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))

Alternative Name: GRK 4

Background: GRK4, GPRK2L, GPRK4, G protein-coupled receptor kinase 4, G protein-coupled receptor kinase GRK4, ITI1GRK4 encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene.

Gene ID: 2868

UniProt: P32298

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling