MRGPRX2 antibody (AA 250-330)

Catalog No. ABIN7229756

The Rabbit Polyclonal anti-MRGPRX2 antibody (ABIN7229756) specifically detects MRGPRX2 in ELISA and WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for MRGPRX2 antibody (AA 250-330) (ABIN7229756)

Target: MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRGPRX2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-MRGPRX2 Antibody

Binding Specificity: AA 250-330

Purpose: Rabbit Anti-MRGX2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of MRGX2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human MRGX2 protein at AA range: 250-330

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MRGPRX2

Target: MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))

Alternative Name: MRGX2

Background: Mas-related G-protein coupled receptor member X2Mast cell-specific receptor for basic secretagogues, i.e. Cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed: 25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.

Molecular Weight: 36kD

Gene ID: 117194

UniProt: Q96LB1