GMDS antibody

Catalog No. ABIN7228678

This Rabbit Polyclonal antibody specifically detects GMDS in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for GMDS antibody (ABIN7228678)

Target: GMDS (GDP-Mannose 4,6-Dehydratase (GMDS))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GMDS antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-GMDS Antibody

Purpose: Rabbit Anti-GMDS Polyclonal Antibody

Specificity: The antibody detects endogenous levels of GMDS protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human GMDS protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GMDS

Target: GMDS (GDP-Mannose 4,6-Dehydratase (GMDS))

Alternative Name: GMDS

Background: GDP-mannose 4,6 dehydratase , GDP-D-mannose dehydratase, GMDGDP-mannose 4,6-dehydratase catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020). GMDS (GDP-Mannose 4,6-Dehydratase) is a Protein Coding gene. Diseases associated with GMDS include Congenital Disorder Of Glycosylation, Type Iic and Partial Fetal Alcohol Syndrome. Among its related pathways are Amino sugar and nucleotide sugar metabolism and Transport to the Golgi and subsequent modification.

Molecular Weight: 40kD

Gene ID: 2762

UniProt: O60547