Gelsolin antibody

Catalog No. ABIN7228646

The Rabbit Polyclonal anti-Gelsolin antibody is suitable to detect Gelsolin in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for Gelsolin antibody (ABIN7228646)

Target: Gelsolin (GSN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Gelsolin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Gelsolin Antibody

Purpose: Rabbit Anti-GELS Polyclonal Antibody

Specificity: The antibody detects endogenous levels of GELS protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human GELS protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Gelsolin

Target: Gelsolin (GSN)

Alternative Name: GELS

Background: Gelsolin, AGEL, Actin-depolymerizing factor, ADF, BrevinGelsolin encoded by GSN binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for GSN. GSN (Gelsolin) is a Protein Coding gene. Diseases associated with GSN include Amyloidosis, Finnish Type and Lattice Corneal Dystrophy Type Ii. Among its related pathways are Apoptosis and survival Caspase cascade and N-cadherin signaling events.

Molecular Weight: 86kD

Gene ID: 2934

UniProt: P06396

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy