GRID2 antibody (AA 800-880)

Catalog No. ABIN7221306

The Rabbit Polyclonal anti-GRID2 antibody is suitable to detect GRID2 in samples from Human, Rat and Mouse. It has been validated for WB, IF and ELISA.

Quick Overview for GRID2 antibody (AA 800-880) (ABIN7221306)

Target: GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRID2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA

Product Details anti-GRID2 Antibody

Binding Specificity: AA 800-880

Purpose: Rabbit Anti-GluR-δ2 Polyclonal Antibody

Specificity: GluR-δ2 Polyclonal Antibody detects endogenous levels of GluR-δ2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human GluR-delta2 at AA range: 800-880

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IF 1:200-1:1000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GRID2

Target: GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

Alternative Name: GluR-delta2

Background: GRID2, GLURD2, Glutamate receptor delta-2 subunit, GluR delta-2 subunitThe glutamate ionotropic receptor delta type subunit 2 encoded by GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.

Molecular Weight: 113kD

Gene ID: 2895

UniProt: O43424

Pathways: Synaptic Membrane