MGLUR2 + MGLUR3 antibody (AA 800-880)

Catalog No. ABIN7221366

The Rabbit Polyclonal anti-MGLUR2 + MGLUR3 antibody (ABIN7221366) specifically detects MGLUR2 + MGLUR3 in IHC, ELISA, WB and IF. The antibody is reactive with Rat, Human and Mouse samples.

Quick Overview for MGLUR2 + MGLUR3 antibody (AA 800-880) (ABIN7221366)

Target: MGLUR2 + MGLUR3 (GRM2/3) (Glutamate Receptor, Metabotropic 2/3 (GRM2/3))

Reactivity: Rat, Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MGLUR2 + MGLUR3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-MGLUR2 + MGLUR3 Antibody

Binding Specificity: AA 800-880

Purpose: Rabbit Anti-mGluR-2/3 Polyclonal Antibody

Specificity: MGluR-2/3 Polyclonal Antibody detects endogenous levels of mGluR-2/3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human mGluR-2/3 at AA range: 800-880

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:20000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MGLUR2 + MGLUR3

Target: MGLUR2 + MGLUR3 (GRM2/3) (Glutamate Receptor, Metabotropic 2/3 (GRM2/3))

Alternative Name: mGluR-2/3

Background: GRM2, GPRC1B, MGLUR2, Metabotropic glutamate receptor 2, mGluR2, GRM3, GPRC1C, MGLUR3, Metabotropic glutamate receptor 3, mGluR3L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for GRM2.

Molecular Weight: 100kD

Gene ID: 2912, 2913

UniProt: Q14416, Q14832