Glutaredoxin 1 antibody (AA 40-120)

Catalog No. ABIN7228674

The Rabbit Polyclonal anti-Glutaredoxin 1 antibody (ABIN7228674) specifically detects Glutaredoxin 1 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Glutaredoxin 1 antibody (AA 40-120) (ABIN7228674)

Target: Glutaredoxin 1 (GRX1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutaredoxin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Glutaredoxin 1 Antibody

Binding Specificity: AA 40-120

Purpose: Rabbit Anti-GLRX1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of GLRX1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human GLRX1 protein at AA range: 40-120

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Glutaredoxin 1

Target: Glutaredoxin 1 (GRX1)

Alternative Name: GLRX1

Background: Glutaredoxin-1, Thioltransferase-1, TTase-1GLRX encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.

Molecular Weight: 11kD

Gene ID: 2745

UniProt: P35754

Pathways: Cell RedoxHomeostasis